Restylane (Medicis) and Juvederm (Allergan) are sterile gels that can be used to rejuvenate the face and restore lost volume for fuller lips and reduction of wrinkles. Also known as dermal fillers, they are made from hyaluronic acid gel. This is a natural carbohydrate found in the tissues of all vertebrate animals. Because of this, no skin testing for allergies is required. To further enhance safety, the hyaluronic acid used is derived from a non-animal source by using genetically engineered bacteria to produce it. They contain no human or animal DNA.
The advantage of hyaluronic acid is that it can last up to twice as long as collagen. Patients can expect it to last for at least 6 months. There are a variety of preparations available with different consistencies, each suited to a particular anatomical area.